A preliminary sleep study involving healthy human volunteers suggests that CBD acts as an anxiolytic.12 This preliminary finding has also been replicated in animal models.39 In a larger case study of human individuals with anxiety and sleep complaints, 79.2% (57 out of 72) of patients had decreased anxiety scores and 66.7% (48 out of 72) of patients had improved sleep in the first month, fluctuating in subsequent months.40 In a simulated public speaking task, involving healthy humans, CBD was shown to reverse the anxiogenic effects of Δ9-THC and reduce anxiety.18 There are also preclinical studies that indicate that CBD may also be used as an adjuvant in exposure-based psychotherapies for anxiety disorders.41


Shannon, S., et al. Cannabidiol in Anxiety and Sleep: A Larger Case Series. Perm J 2019;23:18-041.